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2 days ago

Marijuana OSP

The endocannabinoid system is connected to various neurological disorders. While researchers work diligently to figure out the whys and hows, we don’t have to wait to start helping our children. Supplementing with plant based cannabinoids can potentially alleviate some of their symptoms. 🙌🏼

Role of the endocannabinoid system in neurological disorders; M Zou, et al., 2019

The endocannabinoid (eCB) system is an important regulatory system of the central nervous system that regulates neurotransmission and synaptic plasticity and is not only involved in many aspects of human health and disease, but also plays a key role in emotion, social responses, and cognitive functions. The association between eCB system abnormalities and various neurological diseases such as schizophrenia, depression, anxiety, and epilepsy has been demonstrated, and changes in eCB levels have been observed in these mental illnesses. As such, it is no surprise that ASD also involves the eCB system.

In recent years, studies have also suggested that eCB system is associated with important functions in the development of the ASD-related nervous system (learning and memory, cognitive function, etc.). Evidence from human and animal models demonstrates that the main components of the eCB system are perturbed in the brain of ASD patients.

Despite these inconsistencies, researchers generally agree that eCB are an important tache in the pathophysiology of various neuropsychiatric disorders. The role of eCB metabolic pathway regulation is complex, eCB can function either directly or through a large amount of metabolites, but our understanding of the eCB's signaling mechanism in ASD is still in its infancy.

To date, most of what has been described pertains to AEA and 2-AG and relatively little is known about the roles of PEA and OEA. Further research on eCB signaling and eCB clinical intervention should be conducted in the future. The metabolic enzymes of the eCB system as well as key enzymes in oxidative pathways such as COX appear to be promising targets for ASD therapy. This review not only provides a scientific basis for further targeted nutrition interventions of ASD. Based on this, it also opened the way for the treatment of mental illness by eCB-oriented drugs.

www.sciencedirect.com/science/article/abs/pii/S0736574818302995

Image below from “Lower circulating endocannabinoid levels in children with autism spectrum disorder” (molecularautism.biomedcentral.com/articles/10.1186/s13229-019-0256-6)
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2 days ago

Marijuana OSP

Children and Cannabis #OneSpecialPlant🎉Good News For Jorja🎉

After Jorja's past supplier of her medical cannabis were unable to supply anymore of her treatment until summer, not to mention their dramatic increase in price, Canadian company, Aphria, have stepped in and supplied Jorja's medication FREE of charge. They are covering all associated costs until the NHS step up and help Jorja.

Aphria has saved Jorja's life. We did not know how we could keep going, paying the huge (rising) monthly fees for the medication that has changed Jorja's life.

Baroness Blackwood wrote to us from the UK Health Department to say that they would not pay for Jorja's medication and that anyone who chooses to get medical cannabis themselves, does so at their own cost!

It is disgusting that medical cannabis was made legal on the 1st November 2018, and still no one has had access on the NHS apart from the previous license holders.

Families are suffering across the United Kingdom, mums and dads I have had the privilege of meeting and campaigning with are hurting! Desperately trying to go abroad or trying to find huge sums of money to go private! These families do not want to have to live like this, they want the NHS that they pay for to step up and help their children. They want Matt Hancock to do as he promised and find a solution.

Our family is so thankful to Aphria who are set to make positive change in the UK. They are the first company to put their hands in their pockets when they realised that what is happening is wrong in the UK and support my daughter with her life saving medication - we are so extremely lucky. But they cannot do it forever, the Government must implement medical cannabis in the NHS before more people die!

www.dailymail.co.uk/wires/pa/article-6881701/amp/Private-firm-provide-girl-medical-cannabis-NHS-r...
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